: Beyond polymers
Beyond our product offer we provide you with key know-how to get the most out of the poly(2-oxazoline) platform.
We are experts in preparing tailor-made polymers to help you create innovative products in a wide range of areas. With AVROXA, you assure a scalable supply of high-quality materials, and the confidence of having the support of a world-leading team of experts committed to help you succeed.
We have adapted production methods to meet both the medical and the larger-scale non-medical industries, always providing the highest quality product for your application. AVROXA polymers have very narrow molar mass distributions (dispersities typically < 1.10), and high purity (> 95 %). In addition, we are also able to provide with cGMP grade materials.
We make the polymer you need…
… so you can focus on doing great science
Product range
End-functional and Clickable Polyoxazolines now available at SIGMA-ALDRICH®
Quality directly available at SIGMA-ALDRICH®
- Directly available
- From more hydrophilic than PEG (PMeOx) to thermoresponsive (PnPrOx).
- Different molecular weights from 5 to 50 kDa.
- Six different chain-end functionalities available.
- ULTROXA®: The best quality and molar mass definition in the market.
End-functional and Clickable Poly(2-oxazoline)s
- Surface functionalization (grafting to).
- (Nano)Particle functionalization.
- Confer the desired properties to the substrate of interest: stealth behavior, cell-adhesive/antifouling.
- Ideal for implants, biosensors, imaging.
- Switchable (thermoresponsive) surfaces or nanoparticles.
- Polymer-protein conjugates.
- Half-life extension.
- Increase stability, lower toxicity.
- Surface/Nanoparticle properties.
- Sensors, Smart materials…
Additional functions available, contact us!
Structure-property relationships screening.
We design the optimal polymer for your application.
The polymers shown are either directly available or on request. Contact us for more information.
The polymers shown are either directly available or on request. Contact us for more information.
Side-chain Functional polymers
- Optimal drug-delivery vehicles.
- High drug payload.
- Targeted delivery including antibody-drug conjugates with high DAR.
- Cleavable linkers for controlled delivery of the prodrug (pH-, enzymatically cleavable…).
- Drug depots for long-term sustained drug delivery.
- 3-D cell culture, regenerative medicine.
- Medical devices.
- We design the optimal polymer for your application, contact us.
Hydrogels
Ultra-high Molar Mass PEtOx polymers
- Very narrow molar masss distribution
- High purity.
- High performance excipients.
- Increase API solubilization rate.
- Protect sensitive APIs.
- Contact us to learn more about ULTROXA® excipients benefits.
The polymers shown are either directly available or on request. Contact us for more information.
Thermoresponsive copolymers
- End-functional polymers.
- Bi-functional polymers available on request.
- Tunable solubility properties.
- Transition from hydrophilic to hydrophobic at a defined temperature.
- High complexation ability.
- Surface functionalization.
- Topical formulations.
- Cosmetics and personal care.
The polymers shown are either directly available or on request. Contact us for more information.
Ultra well-defined Linear PEI
- Introduction of functionality (azide, alkyne, allyl, primary amine…) at the polymer chain ends.
- Introduce moieties –e.g. fluorescence or other imaging probes- to your drug-delivery vector.
- Optimized polymer chain length for transfection.
- PAOx-PEI/POZ-PEI copolymers: Absolute control over the degree of hydrolysis.
- Ultra-defined polymers (Đ < 1.1).
- We design the optimal polymer for your application.
The polymers shown are either directly available or on request. Contact us for more information.
Amphiphilic gradient and block-copolymers: PEtOx-co-PPhOx
- Amphiphilic copolymers for micelle formation.
- introduce targeting/tracking groups on the micelle corona via click chemistry for enhanced drug delivery.
- Tunable particle structure and size by modification of the polymer length and composition.
- Formulation, cosmetics and personal care, drug delivery.
The polymers shown are either directly available or on request. Contact us for more information.